2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Melanocortin Receptor

Melanocortin Receptor

MC Receptor

Melanocortin Receptor

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The melanocortin (MC) receptors represent a subfamily of G-protein-coupled receptors (GPCRs) where the different subtypes are involved in a wide range of physiological functions such as pigmentation, steroid secretion, energy homeostasis, and food intake. The melanocortin receptor (MCR) family consists of five G-protein-coupled receptors (MC1R-MC5R). MC1R controls pigmentation, MC2R is a critical component of the hypothalamic-pituitary-adrenal axis, MC3R and MC4R have a vital role in energy homeostasis and MC5R is involved in exocrine function.

MCRs are activated by a variety of neuropeptides, termed melanocortins, that include the adrenocorticotropic hormone (ACTH) andα, β and γ-melanocyte-stimulating hormones (MSHs). Melanocortins derive from post-translational processing of the common polypeptide precursor pro-opiomelanocortin, expressed mainly in the hypothalamus and pituitary.

Melanocortin Receptor Isoform Specific Products:

Melanocortin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P3068
    ACTH (1-16) (human)
    		99.95%
    ACTH (1-16) (human) (Adrenocorticotropic hormone (1-16)) is an ACTH fragment. ACTH (1-16) (human) improves cardiovascular function and survival in experimental hemorrhagic shock.
    ACTH (1-16) (human)
  • HY-P99004
    hMC1R agonist 1
    		Antagonist
    (EC50=3 nM). hMC1R agonist 1 shows at least 300-fold selectivity for hMC1R over hMC3R (b>EC50=902 nM), hMC4R (b>EC50=915 nM), and hMC5R (b>EC50=>1000 nM). hMC1R agonist 1 has the potential for the therapeutic intervention of melanocortin family.
    hMC1R agonist 1
  • HY-P1216A
    HS014 TFA
    		Antagonist 99.87%
    HS014 TFA is a potent and selective melanocortin-4 (MC4) receptor antagonist, with Kis of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors respectively. HS014 TFA increases food intake in free-feeding rats.
    HS014 TFA
  • HY-P5247A
    Palmitoyl tetrapeptide-20 TFA
    		Activator
    Palmitoyl tetrapeptide-20 (PTP20) TFA is a biomimetic peptide agonist of α-MSH. Palmitoyl tetrapeptide-20 TFA promotes hair pigmentation and delays hair graying by activating the MC1-R pathway (AC50: 0.16 nM), enhancing catalase activity to reduce H2O2 accumulation, and upregulating SIRT1 activity. Palmitoyl tetrapeptide-20 TFA can be used in research on preventing hair loss and improving hair graying.
    Palmitoyl tetrapeptide-20 TFA
  • HY-P0060A
    Tetracosactide acetate
    		Agonist 99.53%
    Tetracosactide acetate (Tetracosactrin acetate ) is the acetate salt form of Tetracosactide (HY-P0060). Tetracosactide acetate is an analogue of adrenocorticotrophic hormone (ACTH). Tetracosactide acetate is the agonist for melanocortin-4 receptor (MC4R) that activates human MC4R with an EC50 of 0.65 nM. Tetracosactide acetate can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide acetate is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis.
    Tetracosactide acetate
  • HY-11030
    SNT-207858
    		Antagonist
    SNT207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.
    SNT-207858
  • HY-P1503
    ACTH (4-11)
    		98.48%
    ACTH (4-11), an adrenocorticotropin hormone fragment, possesses a weak α-melanocyte stimulating hormone (α-MSH) potency only at high doses (100 and 1000 nM).
    ACTH (4-11)
  • HY-P5248
    Tetrapeptide-1
    		Agonist 99.80%
    Tetrapeptide-1 is a bioactive peptide with antioxidant effect and has been reported used as a cosmetic ingredient.
    Tetrapeptide-1
  • HY-P1922
    γ-2-MSH (41-58), amide
    		Agonist 98.80%
    γ-2-MSH (41-58), amide is derived from γ-2-MSH. γ-2-MSH is a twelve amino acid peptide that is derived from the N-terminal fragment of proopiomelanocortin (POMC) and contains the His-Phe-Arg-Trp motif common to all melanocortin endogenous agonist ligands.
    γ-2-MSH (41-58), amide
  • HY-P1739
    ACTH (34-39)
    		99.88%
    ACTH (34-39) is an adrenocorticotropic hormone fragment. ACTH (34-39) can be used in the study of stress-related sleep disorders.
    ACTH (34-39)
  • HY-P1558A
    ACTH (11-24) (acetate)
    		Antagonist 99.88%
    ACTH (11-24) (acetate) is an adrenocorticotropic hormone (ACTH) receptor antagonist. ACTH (11-24) is a fragment of adrenocorticotropic and induces cortisol release. ACTH (11-24) can be used for the research of central nervous system.
    ACTH (11-24) (acetate)
  • HY-P10571
    GPS1573
    		Antagonist
    GPS1573 is a noncompetitive antagonist of melanocortin type 2 receptor (MC2R) that dose-dependently antagonizes ACTH-stimulated MC2R activity (IC50=66 nM). GPS1573 can be used in the study of Cushing's disease due to its highly selective antagonism of MC2R.
    GPS1573
  • HY-P1518
    Adrenocorticotropic Hormone (ACTH) (1-10), human
    		98.26%
    Adrenocorticotropic Hormone (ACTH) (1-10), human, an adrenocorticotropin hormone fragment, possesses a weak α-melanocyte stimulating hormone (α-MSH) potency only at high doses (100 and 1000 nM).
    Adrenocorticotropic Hormone (ACTH) (1-10), human
  • HY-19870C
    Setmelanotide monoacetate
    		Agonist 99.71%
    Setmelanotide (monoacetate) is a melanocortin 4 receptor (MC4R) agonist that acts on human and rat MC4R with EC50 values of 0.27 nM and 0.28 nM, respectively.
    Setmelanotide monoacetate
  • HY-148349A
    (2R,2R)-PF-07258669
    		Antagonist
    (2R,2R)-PF-07258669 is a MC4R (melanocortin 4 receptor) antagonist. (2R,2R)-PF-07258669 can be used in the study of regulating appetite and energy expenditure.
    (2R,2R)-PF-07258669
  • HY-P3645
    (Nle4)-α-MSH
    		Agonist
    (Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment.
    (Nle4)-α-MSH
  • HY-P1869
    Neuropeptide EI, rat
    		Agonist
    Neuropeptide EI, rat displays functional melanin concentrating hormone (MCH)-antagonist and melanocyte-stimulating hormone (MSH) agonist activity in different behavioral paradigms.
    Neuropeptide EI, rat
  • HY-P3981
    Defensin NP-3A
    		Inhibitor
    Defensin NP-3A (NP-3A; Corticostatin 1) is a human granulocyte peptide, with anti-ACTH activity. Defensins are antimicrobial peptides with and cytotoxic activity.
    Defensin NP-3A
  • HY-P3659
    (D-Phe7)-α-MSH
    (D-Phe7)-α-MSH is an α-MSH analogue.
    (D-Phe7)-α-MSH
  • HY-RS08210
    Mc4r Mouse Pre-designed siRNA Set A
    		Inhibitor

    Mc4r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mc4r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mc4r Mouse Pre-designed siRNA Set A
    Mc4r Mouse Pre-designed siRNA Set A
Cat. No. Product Name / Synonyms Application Reactivity
Melanocortin Receptor Isoform Comparison

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